Comparative study of silicone-hydrogel contact lenses surfaces before and after wear

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Comparative study of silicone-hydrogel contact lenses surfaces before and after wear using atomic force microscopy. J Biomed Mater Res B Appl Biomater. 2008 May;85(2):361-7 Authors: Lira M, Santos L, Azeredo J, Yebra-Pimentel E, Oliveira ME PURPOSE: The aim of this study was to analyze surface changes of three silicone-hydrogel contact lenses after daily wear. The lenses used in this study were balafilcon A, lotrafilcon B (both surface-treated), and galyfilcon A (non surface-treated). METHODS: To understand how and where proteins, lipids, and other contaminants change contact lenses, surface roughness was assessed through Atomic Force Microscopy Tapping Mode. Roughness parameters were Mean Surface roughness (R(a)), Mean-square-roughness (R(q)), and Maximum roughness (R(max)). The surface topography of unworn and worn lenses was also mapped in great detail. RESULTS: Contact lenses roughness parameters exhibited different values before and after wear and the surface appearance also changed. After wear, balafilcon A and galyfilcon A showed a significant increase on surface roughness parameters, being this increase more accentuated to galyfilcon A. In lotrafilcon B materials no significant changes were observed with wear. CONCLUSIONS: The present study suggests that surface treatment of silicone-hydrogel contact lenses can play a role in the prevention of a significant increase in roughness, and contribute to the better clinical tolerance of these lenses. PMID: 17957701 [PubMed - indexed for MEDLINE]

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