Comparison of virulence factors in Pseudomonas aeruginosa strains isolated from conta

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Comparison of virulence factors in Pseudomonas aeruginosa strains isolated from contact lens- and non-contact lens-related keratitis. J Med Microbiol. 2008 Dec;57(Pt 12):1539-1546 Authors: Choy MH, Stapleton F, Willcox MD, Zhu H Pseudomonas aeruginosa is one of the common pathogens associated with corneal infection, particularly in contact lens-related keratitis events. The pathogenesis of P. aeruginosa in keratitis is attributed to the production of virulence factors under certain environmental conditions. The aim of this study was to determine differences in the virulence factors of P. aeruginosa isolated from contact lens- and non-contact lens-related keratitis. Associations were assessed between type III secretion toxin-encoding genes, protease profiles, biofilm formation, serotypes and antibiotic-resistance patterns among 27 non-contact lens- and 28 contact lens-related P. aeruginosa keratitis isolates from Australia. Strains with a exoS(+)/exoU(-) genotype and a type I protease profile predominated in the non-contact lens-related keratitis isolates, whereas the exoS(-)/exoU(+) and a type II protease profile was associated with contact lens-related isolates (P