Personalized 'eye-in-a-dish' models reveal genetic underpinnings of macular degeneration
Date:
May 9, 2019
Source:
University of California - San Diego
Summary:
Using stem cells derived from six people, researchers recapitulated retinal cells in the lab. This 'eye-in-a-dish' model allowed them to identify genetic variants that cause age-related macular degeneration, a common cause of vision loss.
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Materials provided by University of California - San Diego. Original written by Heather Buschman, PhD. Note: Content may be edited for style and length.
Journal Reference:
University of California - San Diego. "Personalized 'eye-in-a-dish' models reveal genetic underpinnings of macular degeneration." ScienceDaily. ScienceDaily, 9 May 2019. <www.sciencedaily.com/releases/2019/05/190509125155.htm>.
Date:
May 9, 2019
Source:
University of California - San Diego
Summary:
Using stem cells derived from six people, researchers recapitulated retinal cells in the lab. This 'eye-in-a-dish' model allowed them to identify genetic variants that cause age-related macular degeneration, a common cause of vision loss.
Share:
Materials provided by University of California - San Diego. Original written by Heather Buschman, PhD. Note: Content may be edited for style and length.
Journal Reference:
- Erin N. Smith, Agnieszka D'Antonio-Chronowska, William W. Greenwald, Victor Borja, Lana R. Aguiar, Robert Pogue, Hiroko Matsui, Paola Benaglio, Shyamanga Borooah, Matteo D'Antonio, Radha Ayyagari, Kelly A. Frazer. Human iPSC-Derived Retinal Pigment Epithelium: A Model System for Prioritizing and Functionally Characterizing Causal Variants at AMD Risk Loci. Stem Cell Reports, 2019; DOI: 10.1016/j.stemcr.2019.04.012
University of California - San Diego. "Personalized 'eye-in-a-dish' models reveal genetic underpinnings of macular degeneration." ScienceDaily. ScienceDaily, 9 May 2019. <www.sciencedaily.com/releases/2019/05/190509125155.htm>.