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Macular Degeneration

Discussion in 'General Topics' started by Michael Margaretten, May 11, 2019.

  1. Michael Margaretten

    319
    Messages
    Joined:
    Jul 17, 2001
    School/Org:
    Pennsylvania College of Optometry
    City:
    Hollywood
    State:
    FL
    Personalized 'eye-in-a-dish' models reveal genetic underpinnings of macular degeneration
    Date:
    May 9, 2019
    Source:
    University of California - San Diego
    Summary:
    Using stem cells derived from six people, researchers recapitulated retinal cells in the lab. This 'eye-in-a-dish' model allowed them to identify genetic variants that cause age-related macular degeneration, a common cause of vision loss.
    Share:
    Materials provided by University of California - San Diego. Original written by Heather Buschman, PhD. Note: Content may be edited for style and length.

    Journal Reference:

    1. Erin N. Smith, Agnieszka D'Antonio-Chronowska, William W. Greenwald, Victor Borja, Lana R. Aguiar, Robert Pogue, Hiroko Matsui, Paola Benaglio, Shyamanga Borooah, Matteo D'Antonio, Radha Ayyagari, Kelly A. Frazer. Human iPSC-Derived Retinal Pigment Epithelium: A Model System for Prioritizing and Functionally Characterizing Causal Variants at AMD Risk Loci. Stem Cell Reports, 2019; DOI: 10.1016/j.stemcr.2019.04.012
    Cite This Page:

    University of California - San Diego. "Personalized 'eye-in-a-dish' models reveal genetic underpinnings of macular degeneration." ScienceDaily. ScienceDaily, 9 May 2019. <www.sciencedaily.com/releases/2019/05/190509125155.htm>.